Progression of peripheral blood mononuclear cell mitochondrial function during the early phase of sepsis in intensive care unit patients

Abstract Sepsis is associated with high rates of multiorgan failure and mortality. Altered mitochondrial function is an essential component of the early sepsis syndrome. However, its progression over time in peripheral blood mononuclear cells (PBMCs) is thus far unclear. Our purpose was to investiga...

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Autores principales:	Hanneke P. F. X. Moonen, Rianne Slingerland-Boot, Jelle C. B. C. de Jong, Anaïs M. T. Y. Wiech, Arie G. Nieuwenhuizen, Sander Grefte, Arthur R. H. van Zanten
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Colección:	Scientific Reports
Materias:	Immunoparalysis PBMC Respiration Critical illness Metabolism
Acceso en línea:	https://doi.org/10.1038/s41598-026-39202-2
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