Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes.
HIV-1 envelope (Env) is a trimer of gp120-gp41 heterodimers, synthesized from a precursor gp160 that contains an ER-targeting signal peptide (SP) at its amino-terminus. Each trimer is swathed by ~90 N-linked glycans, comprising complex-type and oligomannose-type glycans, which play an important role...
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| Asıl Yazarlar: | , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science (PLoS)
2020-12-01
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| Seri Bilgileri: | PLoS Pathogens |
| Online Erişim: | https://doi.org/10.1371/journal.ppat.1009185 |
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