Pentagamavunone-1 inhibits aggressive breast cancer cell proliferation through mitotic catastrophe and ROS-mediated activities: in vitro and in vivo studies

Pentagamavunone-1 (PGV-1), an analog of curcumin, has been studied for its cytotoxic effects in 4T1, MCF7, MCF7/HER2, and T47D breast cancer cells. Its antiproliferative effect is partly mediated through G2/M arrest; however, its molecular mechanism during cell cycle progression remains unknown. In...

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Autori principali:	Dhania Novitasari, Ikuko Nakamae, Riris Istighfari Jenie, Noriko Yoneda-Kato, Jun-ya Kato, Edy Meiyanto
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2024-01-01
Serie:	Saudi Pharmaceutical Journal
Soggetti:	Curcumin analog Mitotic arrest ROS generation Breast cancer
Accesso online:	http://www.sciencedirect.com/science/article/pii/S1319016423003870
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