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Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

The process of cell fate determination has been depicted intuitively as cells travelling and resting on a rugged landscape, which has been probed by various theoretical studies. However, few studies have experimentally demonstrated how underlying gene regulatory networks shape the landscape and henc...

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Détails bibliographiques
Auteurs principaux: Fuqing Wu, Ri-Qi Su, Ying-Cheng Lai, Xiao Wang
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications Ltd 2017-04-01
Collection:eLife
Sujets:
Accès en ligne:https://elifesciences.org/articles/23702
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