DNA dynamics during early double-strand break processing revealed by non-intrusive imaging of living cells.

Chromosome breakage is a major threat to genome integrity. The most accurate way to repair DNA double strand breaks (DSB) is homologous recombination (HR) with an intact copy of the broken locus. Mobility of the broken DNA has been seen to increase during the search for a donor copy. Observing chrom...

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Principais autores:	Hicham Saad, Franck Gallardo, Mathieu Dalvai, Nicolas Tanguy-le-Gac, David Lane, Kerstin Bystricky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-03-01
coleção:	PLoS Genetics
Acesso em linha:	http://europepmc.org/articles/PMC3952824?pdf=render
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