RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions

Abstract The retinoblastoma protein (RB) is a well-characterized repressor of E2F transcriptional activity that controls genes involved in cell proliferation during the G1 phase. Here, we examine the effect of RB on chromatin organization and uncover a non-canonical role for RB in which it promotes...

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Autori principali:	Hanjun Lee, Ioanna-Maria Gkotinakou, Connor G. McGrath, Badri Krishnan, Sambhavi Animesh, Isabella Salinas, Robert Morris, Moshe Sade-Feldman, Wilhelm Haas, Michael S. Lawrence, Ioannis Sanidas
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-04-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-71655-x
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