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Influence of Combinations of Lipophilic and Phosphate Backbone Modifications on Cellular Uptake of Modified Oligonucleotides

Numerous types of oligonucleotide modifications have been developed since automated synthesis of DNA/RNA became a common instrument in the creation of synthetic oligonucleotides. Despite the growing number of types of oligonucleotide modifications under development, only a few of them and, moreover,...

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Principais autores: Timofey D. Zharkov, Oleg V. Markov, Sergey A. Zhukov, Svetlana N. Khodyreva, Maxim S. Kupryushkin
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-01-01
Serier:Molecules
Fag:
lipophilic oligonucleotides
phosphate modifications
phosphoryl guanidine
triazinyl phosphoramidate
conjugates
delivery
Online adgang:https://www.mdpi.com/1420-3049/29/2/452
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