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Development of Processes for Recombinant L-Asparaginase II Production by <i>Escherichia coli</i> Bl21 (De3): From Shaker to Bioreactors

Since 1961, L-asparaginase has been used to treat patients with acute lymphocytic leukemia. It rapidly depletes the plasma asparagine and deprives the blood cells of this circulating amino acid, essential for the metabolic cycles of cells. In the search for viable alternatives to produce L-asparagin...

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Principais autores: Thaís Barros, Larissa Brumano, Marcela Freitas, Adalberto Pessoa, Nádia Parachin, Pérola O. Magalhães
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-12-01
Serier:Pharmaceutics
Fag:
L-asparaginase
<i>Escherichia coli</i>
IPTG
lactose
shaker
bioreactor
Online adgang:https://www.mdpi.com/1999-4923/13/1/14
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