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The janus-faced biology of GPNMB: from tissue homeostasis to cancer pathogenesis

Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that differentially regulates tissue homeostasis and disease pathogenesis. In physiological contexts, it maintains melanosome biogenesis, osteogenesis, and neuroprotection through domain-specific interactions. Pat...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Cheng Long, Li Qin Yun, Ma Dai Yuan, Imad Ibrahim Ali Al-Sultan
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2025-10-01
Rangatū:Frontiers in Molecular Biosciences
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1664764/full
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