The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma

The efficacy of immunotherapy in pancreatic ductal adenocarcinoma (PDAC) remains limited. The tumor microenvironment (TME), characterized by the accumulation of suppressive myeloid cells including neutrophils, attributes to immunotherapy resistance in PDAC. IgA monoclonal antibodies (mAbs) can activ...

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Autors principals:	Léon Raymakers, Elsemieke M. Passchier, Meggy E. L. Verdonschot, Mitchell Evers, Chilam Chan, Karel C. Kuijpers, G. Mihaela Raicu, I. Quintus Molenaar, Hjalmar C. van Santvoort, Karin Strijbis, Martijn P. W. Intven, Lois A. Daamen, Jeanette H. W. Leusen, Patricia A. Olofsen
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-04-01
Col·lecció:	Cells
Matèries:	IgA monoclonal antibodies mAbs neutrophils polymorphonuclear cells PMNs
Accés en línia:	https://www.mdpi.com/2073-4409/14/9/632
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