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Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome

Background. Lynch Syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC) and extracolonic tumors. The aim of this s...

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Автори: Jose Miguel Moreno-Ortiz, María de la Luz Ayala-Madrigal, Jorge Román Corona-Rivera, Manuel Centeno-Flores, Víctor Maciel-Gutiérrez, Ramón Antonio Franco-Topete, Juan Armendáriz-Borunda, Erin Hotchkiss, Lucia Pérez-Carbonell, Jennifer Rhees, Clement Richard Boland, Melva Gutiérrez-Angulo
Формат: Artigo
Мова:Inglês
Опубліковано: Wiley 2016-01-01
Серія:Gastroenterology Research and Practice
Онлайн доступ:http://dx.doi.org/10.1155/2016/5278024
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