HER2 amplification level by in situ hybridization predicts survival outcome in advanced HER2-positive breast cancer treated with pertuzumab, trastuzumab, and docetaxel regardless of HER2 IHC results

Abstract Background The role of HER2 amplification level in predicting the effectiveness of HER2-directed therapies has been established. However, its association with survival outcomes in advanced HER2-positive breast cancer treated with dual HER2-blockade remains unexplored. Methods This is a sing...

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Principais autores:	Jeongmin Seo, Jiwon Koh, Dae-Won Lee, Jinyong Kim, Han Suk Ryu, Kyung-Hun Lee, Tae-Yong Kim, Seock-Ah Im
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-12-01
coleção:	Breast Cancer Research
Assuntos:	HER2 positive breast cancer HER2/CEP17 ratio HER2 copy number HER2 in situ hybridization Dual HER2 blockade
Acesso em linha:	https://doi.org/10.1186/s13058-023-01746-w
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