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Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration

The expression of fibroblast growth factors (Fgf) ligands in a specialized epithelial compartment, the Apical Ectodermal Ridge (AER), is a conserved feature of limb development across vertebrate species. In vertebrates, Fgf 4, 8, 9, and 17 are all expressed in the AER. An exception to this paradigm...

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Autors principals: Giacomo L Glotzer, Pietro Tardivo, Elly M Tanaka
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications Ltd 2022-05-01
Col·lecció:eLife
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Accés en línia:https://elifesciences.org/articles/79762
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