HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilization

Abstract Sonic Hedgehog signaling is aberrantly activated in non-small cell lung cancer (NSCLC). However, the regulatory molecules of Sonic Hedgehog signaling during NSCLC development are still largely unknown. Here, we demonstrated that HHIP Like 2 (HHIPL2) is a crucial Sonic Hedgehog signaling reg...

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Detalhes bibliográficos

Principais autores:	Ning Mu, Fanrong Liu, Xiangqing Song, Biao Wang, Yilin Zhu, Lingbing Li, Lingxiao Yang, Huacong Sui, Jinfu Wang, Fengyuan Gao, Yongjia Zhou, Yanfeng Lv, Zhongxian Tian, Peichao Li, Xiaogang Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2025-12-01
coleção:	Cell Death and Disease
Acesso em linha:	https://doi.org/10.1038/s41419-025-08331-3
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