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ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Abstract Upon fertilization, the mouse zygotic genome is activated and maternal RNAs as well as proteins are degraded. Early developmental programs are built on proteins encoded by zygotic mouse genes that are needed to guide early cell fate commitment. The box C/D snoRNA ribonucleoprotein (snoRNP)...

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Principais autores: Guanghui Yang, Qiliang Xin, Jurrien Dean
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-06-01
Serier:Advanced Science
Fag:
box C/D snoRNA
embryo development
first cell fate commitment
ribosomal RNA
SMARM‐seq
snoRNP complex
Online adgang:https://doi.org/10.1002/advs.202413599
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