Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis

Leishmaniasis is a disease caused by Leishmania spp., affecting millions of people around the world. For decades, its treatment has been based on pentavalent antimonials, which notoriously cause toxic side effects in patients. In this study, epoxy-α-lapachone incorporated into an oil-in-water-type m...

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Principais autores:	Juliana Figueiredo Peixoto, Luiz Filipe Gonçalves-Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Léa Cysne Finkelstein, Geovane Dias-Lopes, Beatriz Ferreira de Carvalho Patricio, Carolina Guimarães de Souza Lima, Helvécio Vinícius Antunes Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Bernardo Acácio Santini Pereira, Carlos Roberto Alves
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2024-04-01
סדרה:	International Journal for Parasitology: Drugs and Drug Resistance
נושאים:	Leishmania (Leishmania) amazonensis Cutaneous leishmaniasis treatment Combination therapy Meglumine antimoniate Glucantime Epoxy-α-lapachone
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S221132072400006X
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