DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients’ airway epithelial cells

Abstract Molecular changes underlying the persistent health effects after SARS-CoV-2 infection remain poorly understood. To discern the gene regulatory landscape in the upper respiratory tract of COVID-19 patients, we performed enzymatic DNA methylome and single-cell RNA sequencing in nasal cells of...

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Principais autores:	Marey Messingschlager, Sebastian D Mackowiak, Maria Theresa Voelker, Matthias Bieg, Jennifer Loske, Robert Lorenz Chua, Johannes Liebig, Sören Lukassen, Loreen Thürmann, Anke Seegebarth, Sven Twardziok, Daria Doncevic, Carl Herrmann, Stephan Lorenz, Sven Klages, Fridolin Steinbeis, Martin Witzenrath, Florian Kurth, Christian Conrad, Leif E Sander, Naveed Ishaque, Roland Eils, Irina Lehmann, Sven Laudi, Saskia Trump
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Springer Nature 2025-03-01
סדרה:	EMBO Molecular Medicine
נושאים:	Whole-genome DNA Methylation Sequencing scRNA-seq COVID-19 Post-COVID-19 Condition Nasal Mucosa
גישה מקוונת:	https://doi.org/10.1038/s44321-025-00215-5
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