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Soluble TIM-3, likely produced by myeloid cells, predicts resistance to immune checkpoint inhibitors in metastatic clear cell renal cell carcinoma

Abstract Background Immunotherapies targeting PD-1 and CTLA-4 are key components of the treatment of metastatic clear cell renal cell carcinoma (mccRCC). However, they have distinct safety profiles and resistance to treatment can occur. We assess soluble TIM-3 (sTIM-3) in the plasma of mccRCC patien...

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Principais autores: Ivan Pourmir, Nadine Benhamouda, Thi Tran, Hugo Roux, Joséphine Pineau, Alain Gey, Andyara Munoz, Nesrine Mabrouk, Nicolas Epaillard, Virginie Verkarre, Yann-Alexandre Vano, Eric Tartour, Stéphane Oudard
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-02-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
Clear cell renal cell carcinoma
Soluble TIM-3
Myeloid cells
Biomarkers
Immunotherapy
Immune checkpoints
Online adgang:https://doi.org/10.1186/s13046-025-03293-y
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