In Vivo Clonal Analysis Reveals Random Monoallelic Expression in Lymphocytes That Traces Back to Hematopoietic Stem Cells

Evaluating the epigenetic landscape in the stem cell compartment at the single-cell level is essential to assess the cells’ heterogeneity and predict their fate. Here, using a genome-wide transcriptomics approach in vivo, we evaluated the allelic expression imbalance in the progeny of single hematop...

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Auteurs principaux:	Nadiya Kubasova, Clara F. Alves-Pereira, Saumya Gupta, Svetlana Vinogradova, Alexander Gimelbrant, Vasco M. Barreto
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2022-08-01
Collection:	Frontiers in Cell and Developmental Biology
Sujets:	allele-specific expression random monoallelic expression (RME) allelic imbalance (AI) epigenetics clonal analysis hematopoietic stem cell (HSC)
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fcell.2022.827774/full
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