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Xiaoyao San against depression via glia-mediated neuroinflammation using network pharmacology and experimental validation

Abstract Xiaoyao San (XYS) has been proven effective in treating depression, but its underlying mechanisms remain to be elucidated. This study aims to explore the key phytochemicals and mechanisms of the anti-depressant effects of XYS. We focus on the 16 blood compounds of XYS identified through the...

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Principais autores: Xin-Yi Liu, Yi-Zhi Yan, An-Jun Jiang, Wan-Ying He, Ying-Yan Fang, Chao-Hui Li, Man-Fei Deng, Si-Jie Tan, Peng Zeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-11-01
coleção:Scientific Reports
Assuntos:
Xiaoyao san
Depression
Network pharmacology
Neuroinflammation
Phytochemicals
Lipopolysaccharide
Acesso em linha:https://doi.org/10.1038/s41598-025-23296-1
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