Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia

For hematopoietic stem and progenitor cells (HSPCs), hypoxia is a specific microenvironment known as the hypoxic niche. How hypoxia regulates erythroid differentiation of HSPCs remains unclear. In this study, we show that hypoxia evidently accelerates erythroid differentiation, and autophagy plays a...

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Detalhes bibliográficos

Principais autores:	Jian Li, Cheng Quan, Yun-Ling He, Yan Cao, Ying Chen, Yu-Fei Wang, Li-Ying Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-08-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	erythroid differentiation hypoxia autophagy HSPCs K562 HIF-1
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2022.896893/full
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