Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Glioma stem cells (GSCs) from this aggressive brain cancer have been subject to nononcogene addiction therapeutic strategies, in particular targeting iron and cholesterol metabolic pathways. In this study, we show the small molecule Adaptaquin (AQ) has anti‐GSC effects while sparing neurons, mature...

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Detalles Bibliográficos

Principais autores:	Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2026-02-01
Series:	Molecular Oncology
Assuntos:	Adaptaquin cholesterol deferoxamine glioma stem cells iron nononcogene addiction
Acceso en liña:	https://doi.org/10.1002/1878-0261.70128
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