NELF prevents transcriptional readthrough into DNA replication zones in cancer cells

Abstract Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote uncontrolled growth. Here, we find that expression of NELFCD, a known negative transcription...

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Autori principali:	Chihiro Nakayama, Qi Fang, Yasukazu Daigaku, Yuki Aoi, Shoko Ito, Mami Takahashi, Reo Shimatani, Tamiko Minamisawa, Yagiz Ozturk, Hiroshi Kimura, Ali Shilatifard, Michael Tellier, Takayuki Nojima
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2026-02-01
Serie:	EMBO Reports
Soggetti:	DNA Replication NELF RNA Polymerase II Transcription-replication Conflict Transcription Termination
Accesso online:	https://doi.org/10.1038/s44319-026-00700-z
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