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Plumbagin induces G2/M arrest and apoptosis and ferroptosis via ROS/p38 MAPK pathway in human osteosarcoma cells

Plumbagin (PLB), a naphthoquinone compound, has been proven to have anti-cancer properties in different types of cancers. However, the anti-tumor actions as well as molecular processes in osteosarcoma (OS) remain unclear. This study investigates the underlying mechanisms of PLB in human OS cells in...

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Principais autores: Jintang Li, Hang Gao, Ping Wang, Chao Sun, Zhilin Wei, Xingcheng Yi, Shuyuan Yu, Yanan Zhang, Shuqiang Li
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-09-01
coleção:Alexandria Engineering Journal
Assuntos:
Plumbagin
Osteosarcoma
Apoptosis
Ferroptosis
p38 MAPK
ROS
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1110016824006021
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