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MR1-restricted T cell clonotypes are associated with “resistance” to Mycobacterium tuberculosis infection

T cells are required for protective immunity against Mycobacterium tuberculosis. We recently described a cohort of Ugandan household contacts of tuberculosis cases who appear to “resist” M. tuberculosis infection (resisters; RSTRs) and showed that these individuals harbor IFN-γ–independent T cell re...

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Principais autores: Deborah L. Cross, Erik D. Layton, Krystle K.Q. Yu, Malisa T. Smith, Melissa S. Aguilar, Shamin Li, Elise C. Wilcox, Aude G. Chapuis, Harriet Mayanja-Kizza, Catherine M. Stein, W. Henry Boom, Thomas R. Hawn, Philip Bradley, Evan W. Newell, Chetan Seshadri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2024-05-01
coleção:JCI Insight
Assuntos:
Immunology
Infectious disease
Acesso em linha:https://doi.org/10.1172/jci.insight.166505
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