LEUTX and OTX2 orchestrate totipotency-to-pluripotency transitions and heterogeneity in pEPSCs

Summary: The molecular characteristics of expanded pluripotent stem cells (EPSCs) remain debated. Human EPSCs (hEPSCs) resemble embryos at the 8-cell to morula stage, while mouse EPSCs (mEPSCs) resemble post-implantation epiblasts. This study examines the developmental potential and molecular featur...

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Библиографические подробности

Главные авторы:	Linhui Wu, Peng Su, Delong Li, Kai Zhou, Wenting Song, Juanjuan Shi, Qi Wang, Qianfu Huang, Siyi Hu, Xia Zhang, Xin Liu, Jilong Zhou, Yi-Liang Miao
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-10-01
Серии:	Cell Reports
Предметы:	CP: Developmental biology CP: Stem cell research
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2211124725011568
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