Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents

Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies. ALS-8176, a prodrug of the 4′-chloromethyl-2′-deoxy-2′-fluoro nucleoside ALS-8112, was evaluated in hospitalized infants fo...

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Hlavní autoři:	Mahesh Kasthuri, Chengwei Li, Kiran Verma, Olivia Ollinger Russell, Lyndsey Dickson, Louise McCormick, Leda Bassit, Franck Amblard, Raymond F. Schinazi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-03-01
Edice:	Molecules
Témata:	nucleoside virus polymerase inhibitors respiratory syncytial virus zika dengue west nile chikungunya
On-line přístup:	https://www.mdpi.com/1420-3049/25/6/1258
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