DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

Abstract Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine‐mediated neuromuscular disease caused by a CAG repeat expansion in the androgen receptor (AR) gene. While transcriptional dysregulation is known to play a critical role in the pathogenesis of SBMA, the underlying molecular pathome...

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Bibliografiske detaljer

Principais autores:	Naohide Kondo, Genki Tohnai, Kentaro Sahashi, Madoka Iida, Mayumi Kataoka, Hideaki Nakatsuji, Yutaka Tsutsumi, Atsushi Hashizume, Hiroaki Adachi, Haruki Koike, Keiko Shinjo, Yutaka Kondo, Gen Sobue, Masahisa Katsuno
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer Nature 2019-04-01
Serier:	EMBO Molecular Medicine
Fag:	DNA methylation epigenetics Hes5 RG108 spinal and bulbar muscular atrophy
Online adgang:	https://doi.org/10.15252/emmm.201708547
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