Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency.

The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment. To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super Elongation Complexes (ELL2-SECs) are essential to activate HIV-1 transcription. Des...

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Autors principals:	Zichong Li, Jun Wu, Leonard Chavez, Rebecca Hoh, Steven G Deeks, Satish K Pillai, Qiang Zhou
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2019-01-01
Col·lecció:	PLoS Pathogens
Accés en línia:	https://doi.org/10.1371/journal.ppat.1007498
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