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α:Non–α and Gγ:Aγ globin chain ratios in thalassemia intermedia patients treated with hydroxyurea

Objective: To elucidate the possible ways by which hydroxyurea molecules affect globin chain (α or β-like) synthesis. Methods: A total of 23 thalassemia intermedia patients (13 male and 10 female) aged between 5 and 26 years were treated for five months with 15 mg/(kg·day) of hydroxyurea. Hemoglobin...

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Principais autores: Abbas Najjari, Mohsen Asouri, Ladan Hosseini Gouhari, Haleh Akhavan Niaki, Amir Sasan Mozaffari Nejad, Seyyedeh Masoumeh Eslami, Hassan Abolghasemi, Ramin Ataee, Abdol Ali Ebrahimi, Masoumeh Rezaei Moshaei, Ali Asghar Ahmadi
Format: Artigo
Sprog:Inglês
Udgivet: Wolters Kluwer Medknow Publications 2014-05-01
Serier:Asian Pacific Journal of Tropical Biomedicine
Fag:
Thalassemia intermedia
Globin chain
AUT-PAGE
Hydroxyurea
Hemoglobin
Online adgang:http://www.sciencedirect.com/science/article/pii/S2221169115302641
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