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A novel IgG-based FLT3xCD3 bispecific antibody for the treatment of AML and B-ALL

Background In lymphoid malignancies, the introduction of chimeric antigen receptor T (CAR-T) cells and bispecific antibodies (bsAbs) has achieved remarkable clinical success. However, such immunotherapeutic strategies are not yet established for acute myeloid leukemia (AML), the most common form of...

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Váldodahkkit: Melanie Märklin, Gundram Jung, Jonas S Heitmann, Joseph Kauer, Helmut R Salih, Stefanie Mueller, Bochong Li, Latifa Zekri, Naveen K Mehta, Martin Pfluegler, Kristan Meetze, Isabelle Sindel, Fabian Vogt, Lukas Osburg, Hans-Jörg Bühring, Sebastian Hörner, Patrick A Baeuerle, Jennifer S Michaelson
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMJ Publishing Group 2022-03-01
Ráidu:Journal for ImmunoTherapy of Cancer
Liŋkkat:https://jitc.bmj.com/content/10/3/e003882.full
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