ZNF526 drives tumor growth by enhancing SHMT1-dependent serine metabolism and antioxidant capability in TNBC
Abstract Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options and poor prognosis. Although the single-nucleotide polymorphism rs3810151 (p.Val94Ala) in ZNF526 has been identified as a breast cancer susceptibility locus, the functional role and mechanistic...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BMC
2025-11-01
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| Series: | Molecular Cancer |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1186/s12943-025-02503-7 |
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