Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages.

Francisella tularensis is the causative agent of tularemia. We have previously shown that infection with F. tularensis Live Vaccine Strain (LVS) induces macrophages to synthesize prostaglandin E2 (PGE2). Synthesis of PGE2 by F. tularensis infected macrophages results in decreased T cell proliferat...

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Detalhes bibliográficos

Principais autores:	Matthew Dale Woolard, Lydia M Barrigan, James R Fuller, Adam S Buntzman, Joshua eBryan, Colin eManoil, Tom eKawula, Jeffrey A Frelinger
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2013-02-01
coleção:	Frontiers in Microbiology
Assuntos:	Francisella tularensis Macrophages Prostaglandins Francisella Pathogenicity Island (FPI) intracellular growth
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00016/full
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