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<i>Escherichia coli</i> tRNA 2-Selenouridine Synthase (SelU): Elucidation of Substrate Specificity to Understand the Role of <i>S</i>-Geranyl-tRNA in the Conversion of 2-Thio- into 2-Selenouridines in Bacterial tRNA

The bacterial enzyme tRNA 2-selenouridine synthase (SelU) is responsible for the conversion of 5-substituted 2-thiouridine (R5S2U), present in the anticodon of some bacterial tRNAs, into 5-substituted 2-selenouridine (R5Se2U). We have already demonstrated using synthetic RNAs that transformation S2U...

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Principais autores: Patrycja Szczupak, Malgorzata Sierant, Ewelina Wielgus, Ewa Radzikowska-Cieciura, Katarzyna Kulik, Agnieszka Krakowiak, Paulina Kuwerska, Grazyna Leszczynska, Barbara Nawrot
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
coleção:Cells
Assuntos:
tRNA 2-selenouridine synthase
MBP–SelU fusion protein
modified nucleoside
2-thiouridine
<i>S</i>-geranyl 2-thiouridine
2-selenouridine
Acesso em linha:https://www.mdpi.com/2073-4409/11/9/1522
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