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m6A‐dependent upregulation of DDX21 by super‐enhancer‐driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia

Abstract Background Acute myeloid leukaemia (AML) is a haematological malignancy with unfavourable prognosis. Despite the effectiveness of chemotherapy and targeted therapy, relapse or drug resistance remains a major threat to AML patients. N6‐methyladenosine (m6A) RNA methylation and super‐enhancer...

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Autori principali: Yanchun Zhao, Yutong Zhou, Yu Qian, Wenwen Wei, Xiangjie Lin, Shihui Mao, Jie Sun, Jie Jin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2024-04-01
Serie:Clinical and Translational Medicine
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Accesso online:https://doi.org/10.1002/ctm2.1628
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