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Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders

Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the rate-limiting step of de novo lipogenesis and modulates lipid homeostasis. Although numerous SCD1 inhibitors were tested for treating metabolic disorders both in preclinical and clinic studies, the tissue-specific roles of SCD1 in modulating obes...

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Principais autores: Yangliu Xia, Yang Zhang, Zhipeng Zhang, Nana Yan, Vorthon Sawaswong, Lulu Sun, Wanwan Guo, Ping Wang, Kristopher W. Krausz, Oksana Gavrilova, James M. Ntambi, Haiping Hao, Tingting Yan, Frank J. Gonzalez
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-02-01
Serier:Acta Pharmaceutica Sinica B
Fag:
Obesity
SCD1
MT1
Intestinal epithelium
High-fat diet
Oxidative stress
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211383524004556
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