Mechanisms driving open-closed transitions and dimer stability of the large GTPases hGBP1 and hGBP5

The human guanylate-binding proteins 1 and 5 (hGBP1/5) are key players in innate immunity, vital for defending against intracellular pathogens and mediating membrane-associated immune responses. These protein functions are closely linked to their structural dynamics, making a detailed understanding...

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Bibliografski detalji

Glavni autori:	Bastian F. Bundschuh, Jennifer Loschwitz, Birgit Strodel
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-05-01
Serija:	Frontiers in Molecular Biosciences
Teme:	coiled-coil formation dynamin-like proteins (DLPs) guanylate-binding proteins (GBPs) large GTPases molecular dynamics simulations (MD) open-closed transition
Online pristup:	https://www.frontiersin.org/articles/10.3389/fmolb.2026.1732916/full
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