A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR

Abstract Background hsa_circ_0001727 (circZKSCAN1) has been reported to be a tumor-associated circRNA by sponging microRNAs. Intriguingly, we found that circZKSCAN1 encoded a secretory peptide (circZKSaa) in the liver. The present study aims to elucidate the potential role and molecular mechanism of...

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Autori principali:	Runjie Song, Shuoqian Ma, Jiajia Xu, Xin Ren, Peilan Guo, Huijiao Liu, Peng Li, Fan Yin, Mei Liu, Qiang Wang, Lei Yu, Jiali Liu, Binwei Duan, Nafis A. Rahman, Sławomir Wołczyński, Guangming Li, Xiangdong Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-01-01
Serie:	Molecular Cancer
Soggetti:	HCC circZKSaa Sorafenib mTOR Biomarker
Accesso online:	https://doi.org/10.1186/s12943-023-01719-9
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