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Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4

Leukotrienes (LTs) play major roles in lung immune responses, and LTD4 is the most potent agonist for cysteinyl LT1, leading to bronchoconstriction and tissue remodeling. Here, we studied LT crosstalk between myeloid cells and pulmonary epithelial cells. Monocytic cells (Mono Mac 6 cell line, primar...

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Principais autores: Ana Lukic, Jie Ji, Helena Idborg, Bengt Samuelsson, Lena Palmberg, Susanne Gabrielsson, Olof Rådmark
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-09-01
coleção:Journal of Lipid Research
Assuntos:
arachidonic acid
eicosanoid
inflammation
cancer
lung
macrophage/monocytes
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520309330
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