Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context

Summary: Background: COVID-19 continues to show long-term impacts on our health. Limited effective immune-mediated antiviral drugs have been launched. Methods: We conducted a Mendelian randomization (MR) and colocalization analysis using 26,597 single-cell expression quantitative trait loci (sc-eQT...

Повний опис

Бібліографічні деталі

Автори:	Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Elsevier 2025-03-01
Серія:	EBioMedicine
Предмети:	SARS-CoV-2 Immune cell eQTL Causal mechanisms Drug target prioritization Mendelian randomization
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S2352396425000404
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!