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Hepatotoxicity and efficacy associated with first- and new-generation EGFR-TKIs in patients with NSCLC: a systematic review and meta-analysis

Abstract Background While hepatotoxicity has been widely reported with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), the comparative risk among them remains unclear. This study aimed to directly compare the relative risk (RR) of hepatotoxicity between new-generation (afati...

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Principais autores: Zhe Wang, Jipeng Meng, Guanlin Liu, Yidan Wang, Yi Li, Chengrui Zhang, Yong Liu, Guoxiang Sun
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:BMC Cancer
Fag:
EGFR-TKIs
NSCLC
Hepatotoxicity
Meta-analysis
Online adgang:https://doi.org/10.1186/s12885-025-15330-2
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