Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2

Biosynthesis of the prostaglandin endoperoxide by the cyclooxygenase (COX) enzymes is accompanied by formation of a small amount of 11R-hydroxyeicosatetraenoic acid (HETE), 15R-HETE, and 15S-HETE as by-products. Acetylation of COX-2 by aspirin abrogates prostaglandin synthesis and triggers formation...

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Bibliografski detalji

Glavni autori:	Surafel Mulugeta, Takashi Suzuki, Noemi Tejera Hernandez, Markus Griesser, William E. Boeglin, Claus Schneider
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2010-03-01
Serija:	Journal of Lipid Research
Teme:	cyclooxygenase-2 hydroxy-eicosatetraenoic acid lipoxygenase macrophage circular dichroism
Online pristup:	http://www.sciencedirect.com/science/article/pii/S0022227520305150
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