Finding a Novel Chalcone–Cinnamic Acid Chimeric Compound with Antiproliferative Activity against MCF-7 Cell Line Using a Free-Wilson Type Approach

In this work, we carried out the design and synthesis of new chimeric compounds from the natural cytotoxic chalcone 2′,4′-dihydroxychalcone (2′,4′-DHC, <b>A</b>) in combination with cinnamic acids. For this purpose, a descriptive and predictive quantitative structure–activity relationship (QSAR) mod...

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Autori principali:	Isis A. Y. Ventura-Salazar, Francisco J. Palacios-Can, Leticia González-Maya, Jessica Nayelli Sánchez-Carranza, Mayra Antunez-Mojica, Rodrigo Said Razo-Hernández, Laura Alvarez
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-07-01
Serie:	Molecules
Soggetti:	chalcone cytotoxic activity hybrid molecule QSAR
Accesso online:	https://www.mdpi.com/1420-3049/28/14/5486
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