Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients

Abstract Background Disrupted tricarboxylic acid (TCA) cycle metabolism drives ischemic mitochondrial stress in the pathophysiology of acute myocardial infarction (AMI), yet its clinical prognostic utility remains poorly defined. This study aimed to (1) develop a novel metabolic index quantifying TC...

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Bibliografische Detailangaben

Hauptverfasser:	Ye Wang, Pengyan Wu, Zhanchao Chen, Miao Yan, Yiying Zhang, Shaohong Fang, Shanjie Wang, Bo Yu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-02-01
Schriftenreihe:	BMC Medicine
Schlagworte:	TCA cycle Acute myocardial infarction Diabetes mellitus Methylmalonate Succinate Prognosis
Online-Zugang:	https://doi.org/10.1186/s12916-026-04717-y
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