Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress

In psoriasis and other inflammatory skin diseases, keratinocytes (KCs) secrete chemokines that attract T cells, which, in turn, cause epidermal hyperplasia by secreting proinflammatory cytokines. To date, it remains unclear whether skin-homing T cells, particularly memory T cells, can also be activa...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Christian Orlik, Karina M. Berschneider, Beate Jahraus, Beate Niesler, Emre Balta, Knut Schäkel, Jutta Schröder-Braunstein, Maria Margarida Souto-Carneiro, Yvonne Samstag
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2022-10-01
Sarja:	Frontiers in Immunology
Aiheet:	CD6/CD166/CD318 T cell costimulation T cell metabolism keratinocytes non-professional antigen-presenting cells inflammatory skin diseases
Linkit:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016112/full
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