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Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup

Abstract Background Parent-offspring (PO) regression is a central tool to determine the heritability of phenotypic traits; i.e., the relative extent to which those traits are controlled by genetic factors. The applicability of PO regression to viral traits is unclear because the direction of viral t...

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Autori principali: Nadine Bachmann, Teja Turk, Claus Kadelka, Alex Marzel, Mohaned Shilaih, Jürg Böni, Vincent Aubert, Thomas Klimkait, Gabriel E. Leventhal, Huldrych F. Günthard, Roger Kouyos, the Swiss HIV Cohort Study
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2017-05-01
Serie:Retrovirology
Soggetti:
Heritability
Parent-offspring regression
HIV-1
Set-point viral load
Ornstein–Uhlenbeck process
Mixed-effect model
Accesso online:http://link.springer.com/article/10.1186/s12977-017-0356-3
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