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Timosaponin AIII inhibits gastric cancer growth by the promotion of programmed cell death via the activation of p300/acetyl-p53 and Akt/MEK/ERK signaling

Gastric cancer (GC) is a common cancer and causes severe deaths worldwide, while the current treatment cannot meet its medical needs. Timosaponin AIII (Timo AIII) is an active component isolated from Anemarrhena asphodeloides Bunge, which is a well-known Chinese Materia Medica and has multiple pharm...

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Principais autores: Kaizhen Tang, Wairong Zhao, Jing Zhang, Guangyu Wang, Wenting Shi, Meiyan Yue, Yan Lin, Yanli Fu, Zhongyan Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-07-01
coleção:Frontiers in Pharmacology
Assuntos:
gastric cancer
p53
programmed cell death
timosaponin AIII
zebrafish
p300
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2026.1821689/full
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