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Circulating tumor cell–derived lines exhibit an amoeboid mode of migration

Abstract Epithelial-to-mesenchymal transition (EMT) has been described as a critical step in the metastatic process. Recent studies have detected circulating tumor cells (CTCs) in hybrid EMT-states in the blood of cancer patients, however fully epithelial CTC states were also detected, challenging t...

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Главные авторы: Guillaume Belthier, Veronika te Boekhorst, Zeinab Homayed, Jihane Vitre Boubaker, Fanny Grillet, Marie Alexandra Albaret, Momeneh Foroutan, Geneviève De Sousa, Lucile Canterel-Thouennon, Jean-François Bourgaux, Michel Prudhomme, Emmanuelle Samalin, Thibault Mazard, Gérard Lossaint, Lakhdar Khellaf, Frédéric Hollande, Hichem C. Mertani, Peter Friedl, Julie Pannequin
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Portfolio 2026-04-01
Серии:Scientific Reports
Предметы:
Circulating tumor cells
Amoeboid migration
Colorectal cancer
Metastasis
Mouse models
Human sections
Online-ссылка:https://doi.org/10.1038/s41598-026-46858-3
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