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The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily—Structure, Function, Regulation and Potential Drug-Target Approaches

The SLC9 gene family encodes Na+/H+ exchangers (NHEs), a group of membrane transport proteins critically involved in the regulation of cytoplasmic and organellar pH, cell volume, as well as systemic acid-base and volume homeostasis. NHEs of the SLC9A subfamily (NHE 1–9) are well-known for their role...

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Autori principali: Manuel A. Anderegg, Gergely Gyimesi, Tin Manh Ho, Matthias A. Hediger, Daniel G. Fuster
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-05-01
Serie:Frontiers in Physiology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fphys.2022.898508/full
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