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In vitro characterization of cellular responses elicited by endosomal TLR agonists encapsulated in Qβ virus-like particles

Abstract Background Despite promising clinical data for Toll-like receptor-9 agonists encapsulated in virus-like particles (TLR9a VLPs), the relative potency and mechanisms of TLR7a and dual TLR7/8a VLPs remain undefined. TLR9a VLPs, also known as Vidutolimod or CMP-001 is a novel TLR9a encapsulated...

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Principais autores: M. M. Hasibuzzaman, Briana Ibarra, Ishrat Nourin Khan, Thomas Craig Meagher, Caitlin D. Lemke-Miltner, George J. Weiner, Andrean L. Simons
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2025-11-01
סדרה:BMC Immunology
נושאים:
Vidutolimod
TLR
DCs
T cells
CD4
CD8
גישה מקוונת:https://doi.org/10.1186/s12865-025-00768-7
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